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Unfortunately, this feature is not available in the previous versions However, a more direct method to obtain the SE of EBE is possible with NONMEM® VI using one of the internal variables, POSTV. A Perl based automated utility to calculate the SE of EBE is available in PsN® version 2.2.6 or later.
#NONMEM THETA FIXED EFFECTS PARAMETERS CODE#
Writing one's own code requires careful thinking and programming expertise. Therefore postprocessing after a modeling NONMEM run is necessary to obtain the SE of EBE. The SE of EBE of the inter-subject variability parameter n is not available in the output file of NONMEM®. Also the SE of EBE can be used for simulation considering the uncertainty in the inter-subject variability. The SE of EBE is an enhanced model diagnosis tool to assess the precision of the estimated inter-subject variability parameter n. However the standard error (SE) of the empirical Bayes estimate (EBE) of the inter-subject variability parameter n is not provided in the NONMEM® output file. NONMEM uses inter-subject variability parameter n to describe the individual differences in PK/PD parameters.
#NONMEM THETA FIXED EFFECTS PARAMETERS SOFTWARE#
NONMEM® (NONlinear Mixed Effects Model) is the most widely used software for the population pharmacokinetic/ pharmacodynamic (PK/PD) modeling and simulation, also is the standard tool for drug development as well as regulatory approval. Key Words: NONMEM, Standard error of empirical bayes estimate, Nonlinear mixed effects modeling The computed standard error is in general similar to the results from other post-processing methods and the degree of difference, if any, depends on the employed estimation options. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM ® VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled data for demonstration and to evaluate performance. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. The pharmacokinetics/pharmacodynamics analysis software NONMEM output provides model parameter estimates and associated standard errors. Karlsson3ġPfizer Worldwide Biopharmaceutical Businesses - La Jolla, San Diego, CA 92111, USA, 2Asan Medical Center, University of Ulsan, Seoul 138-736, Korea, 3Uppsala University, Uppsala 75105, Sweden Standard Error of Empirical Bayes Estimate in NONMEM® VIĭongwoo Kang1, Kyun-Seop Bae2, Brett E. Korean J Physiol Pharmacol Vol 16: 97-106, April, 2012.